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Cytotoxic effects of APE on RAW264.7 cells, human PBMCs, and human PMNs The cytotoxic effects of APE on RAW264.7 macrophage cells and human leukocytes, including peripheral blood mononuclear cells (PBMCs) and polymorphonuclear cells (PMNs), were evaluated following 24 h treatment at various concentrations of APE (250, 500, 1000, 2000, and 4000 g/mL)

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On the other hand, rats treated with BSO 4 mmol/kg of body weight twice a day showed significantly decreased levels of GSH and enzymatic activity of CAT, SOD, and GPX in blood and erythrocytes, as well as increased levels of MDA