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Nevertheless, the mean age at death for individuals born between 1985 and 1999 has been 29 years, and earlier diagnosis by newborn screening, treatment with more palatable cystine-depleting agents, and trials with gene therapy are critical current pursuits

It is also prone to oxidation because of the high metabolic activity and can result in less-than-optimal energy production and turn into a condition known as mitochondrial dysfunction which is closely tied to vicious cycle of inflammation and disease progression

The key difference is that collagen and protein support tissue structure, while creatine fuels performance and energy metabolism

Zhang H et al., 2015)