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doi: 10.1186/1476-0711-10-23 202 KimJ

As the target of Gap19 is intracellular, an addition of cell-permeable sequence TAT to Gap19 produced a TATGap19 peptide, which improves the hemichannel inhibitory efficacy (IC 50 ~7 M versus 50 M for Gap19) and makes this formulation to cross blood-brain barrier 515