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GABAergic, serotonergic, noradrenergic, and brain stem cholinergic may also mediate the actions of nicotine on the brain

Today there are a number of European countries, as well as Japan, where the per capita consumption of cigarettes is greater than in the United States (see Figure 5-1)

There is no doubt that EC users quit smoking more recently than non-users (see the previous reviews for the explanation) and because time since quitting is a major predictor of lung cancer risk, this must have contributed to the findings

The rate at which young people and adults start smoking as a result of using e-cigarettes should be assessed and monitored to fill a research gap