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It works by binding directly to the IGF-1 receptor (IGF-1R) on muscle and other tissue, activating the PI3K/Akt and MAPK signaling cascades that drive cell growth and proliferation

Combined oral sodium butyrate and mesalazine treatment compared to oral mesalazine alone in ulcerative colitis

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Coronary atherosclerosis initiates with endothelial damage to the vascular intima, followed by a sequence of events including lipid deposition, vascular smooth muscle cell proliferation, and extracellular matrix synthesis, collectively resulting in arterial wall thickening and progressive luminal narrowing (17)