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Hydroxytyrosol as a Component of the Mediterranean Diet and Its Role in Disease Prevention

In particular, MPTP intoxication typically downregulates key autophagy regulators (LC3-II, beclin-1, parkin, PINK1), but schisandrin A treatment partially preserved the levels of these proteins, implying that it enhances autophagic clearance of toxic aggregates (59, 60)

10.1080/10611860903055470 105 MobarraN.ShanakiM.EhteramH.NasiriH.SahmaniM.SaeidiM.et al (2016)

Iron plays a direct and causal role in the pathogenesis of diabetes mediated by -Cell exhaustion and insulin resistance (Simcox and McClain, 2013), even in the absence of apparent iron overload (Vari et al., 2007), thus precise control of iron levels in the body is critical for maintaining metabolic homeostasis (Wang et al., 2021)