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tarda ( Phialophora species have been linked to patients with immune system impairments, particularly those involving CARD9 (Caspase Recruitment Domain-containing protein 9) deficiencies ( In addition to the clinical relevance, Phialophora species have been investigated for their ecological functions, particularly their capacity to degrade lignin and other complex organic compounds in their natural environments ( Phialophora , as both environmental decomposers and opportunistic pathogens, makes the genus particularly intriguing from both medical mycology and environmental microbiology perspectives ( Phialophora species to thrive in hostile environments, including low oxygen conditions and high irradiation exposure, and likely enhances their resistance to certain host immune responses ( A recent survey exploring ascomycete diversity in freshwater sediments revealed Phialophora strains in both oligotrophic and eutrophic areas of several Spanish rivers, thereby broadening our understanding of the ecological niches occupied by potentially pathogenic fungi ( P