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Antifungal activity of the lipophilic antioxidant Ferrostatin-1

These findings align with previous reports indicating that downstream pathways, particularly PI3K/AKT and mTOR, are responsive to hepsin downregulation (Fig

284,285,286,287,288,289,290 For instance, acute phase of HCV infection induces oxidative stress via enhancing NOXs expression and activity to generate ROS generation and decreasing GSH, which supports the high rates of viral replication and apoptotic cell death

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