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Wyczkowska J, Walczak-Drzewiecka A, Wagner W, Dastych J

To attain sufficient bioavailability for nasally administered proteins and peptides, absorption enhancers, including cyclodextrin, surfactants, and mucoadhesive polymers have been applied in many formulation studies ( 3.2 Pathways of transepithelial transport To reach the bloodstream on the capillaries, drugs have to pass through the mucus barrier

The community starts at doses equivalent to the lowest FDA titration step (0.25 mg) and increases cautiously