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Reproduction studies of acetylcysteine solution with isoproterenol have been performed in rats and of acetylcysteine solution alone in rabbits at doses up to 2.6 times the human dose

Given that the main structural difference between these two enzymes is the presence of a CBM loop insert in Bd GUS, the CBM loop may explain this difference in activity, as it may occlude a substrate like p NPG from being properly positioned in the active site

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