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Written informed consent was obtained from all patients involved in the study

3-Aminopropanal appears to be the main metabolite of polyamine catabolism mediated by FAD-dependent enzymes, which can dissociate into acrolein and ammonia [53]

The TFAP2A/NEL3 axis has also been found to promote M2 polarisation through Gln metabolism, thus providing a theoretical basis for immunotherapy targeting cancer TMEs [119]