glutathione polyol pathway The and the role of aldose reductase in diabetic Polyol pathway. Hyperglycaemia increases flux

Through NRF2-driven GSH synthesis, tumor cells are protected from oxidative stress, which contributes to chemotherapy resistance by reducing the cytotoxic effects of ROS generated during treatment

Glutathione - Synthesis SFRBM Education Program Dickinson et al.5 + NADP NADPH Glutathione Reductase GSSG GSH Glutathione H O H O Peroxidase 2 2 2 LOH LOOH PSSP PSSG PSH Glutathione - redox cycling Glutathione - Synthesis SFRBM Education Program Dickinson et al.6 Glutathione uses and losses The glutathione S-transferases (GST) serve a protective role by adding GSH to a molecule, targeting it for export from the cell

This triple strength lightening complex is known to help even out blemishes

These studies suggested that high levels/activities of TrxR were correlated with melanin formation, providing additional information on the roles of cellular antioxidant proteins in melanogenesis (Table 1)