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Reduced renal clearance can elevate TMAO levels 31

doi: 10.1158/1541-7786.MCR-14-0246 145 YuanJNarayananLRockwellSGlazerPM

Further studies have demonstrated that Kupper cells and hepatocytes act as a major source of circulating pro-inflammatory cytokines, including TNF-, IL-6 and proteolysis inducing factor, in cancer cachexia, via the NF-B- and STAT3-dependent signaling pathways (8), or the cyclooxygenase-2 (Cox2)/prostaglandin E2 (PGE2) pathway (9)

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