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and this suggest that normal wild-type mice have a better stress tolerance than BNDF heterozygous mice [86]

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3.2 DDI network modeling In this study, irreversible inhibition processes of CYP3A4 for voriconazole and tacrolimus and CYP2C19 for omeprazole were modeled using Ki (inhibition constant) and k inact (maximum inactivation rate constant) values ( Ki values ( The performance of DDI models was evaluated by comparing predicted to observed PK profiles of victim drugs with/without an enzyme or transporter perpetrator coadministration (Supplementary Figures S8S14)