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It refers to a state of being upset over something that isnt a big deal, and its used in a derogatory sense to minimize someones reaction

Five hundred microliter of the methylene chloride layer containing the nicotine was then vortexed with 500 l of 50 mM HCl solution and the nicotine of the HCl solution was estimated by HPLC analysis at 254 nm

With the right care and guidance, many patients find a routine that works for them

Ultimately, Judge Jerry Smith ruled that although the warnings were compelled speech, they were both factual and uncontroversial, despite the emotional impacts the graphics may have. The court further ruled that the warnings were justified by a legitimate state interest and were not unduly burdensome on the plaintiffs