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Generally, the schedule for vitamin B 12 replacement is 1 mg daily for a week or 1 mg 3 times a week for 2 weeks, followed by 1 mg per week for 1 month, and then 1 mg per month as maintenance dose.9 Around 1% to 5% of free vitamin B 12 can be absorbed along the entire intestine by passive diffusion

Supplementation of folic acid is also important for patients on certain medicines, such as methotrexate for rheumatoid arthritis, as these medications can reduce folate in the body

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