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As early as a few decades ago, it was shown that the glycocalyx covers the surface of most vascular lumens and that microcirculatory dysfunction and endothelial damage play important roles in the multiorgan failure associated with sepsis (53), and also that endothelial dysfunction and microcirculatory impairment are determinants of the severity and duration of sepsis (54)

USA 119 , e2112040119 (2022)

Producing cell migration, angiogenic, and anti-apoptotic effects particularly pronounced in cardiac, vascular, and wound healing contexts

Optimal results require combining the peptides cellular effects with appropriate nutrition providing caloric deficit, regular cardiovascular exercise to oxidize mobilized fatty acids, and resistance training to preserve muscle mass during fat loss