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The use of FAs rather than carbohydrates when CoA levels are limited could potentially be driven by a lower K m for acyl-CoA synthetases compared with that for pyruvate dehydrogenase 60,61

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Conclusion: These findings define the metabolic and redox circuits driving MPLA-induced antimicrobial immunity and establish its potential as a host-directed antimicrobial therapy beyond vaccine adjuvancy

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