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In our study, the mRNA level of ugt2a2 was upregulated in the HFD group

10.1002/biof.5520260305 2 Al-KuraishyH

Conversely, others and our laboratory have demonstrated that NO can favor GSH synthesis via the NEFL2-mediated transcription of GCL (Baldelli et al., 2008

Indeed, when the effect of 2APB on drug metabolism was evaluated, it was discovered that 2APB is a P450 inhibitor as directly shown in vitro and observed in vivo when the protection correlated with inhibition of protein adduct formation [155]