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Current evidence suggests that high-dose B12 supplementation can trigger acne in susceptible people by altering skin bacteria behaviour, though this does not affect everyone

Without enough B12, these cells can become large and misshapen (megaloblastic anaemia), reducing oxygen flow to your brain and muscles, causing fatigue and weakness

Recent studies have suggested that Vit B12 deficiency along with the induced hyperhomocysteinemia are correlated with specific PD phenotypes characterized with early postural instability and falls and more rapid motor progression, cognitive impairment, visual hallucinations and autonomic dysfunction

As of 2025, AOD-9604 should be regarded as a discontinued research peptide, not a therapeutic agent , with ongoing relevance confined to academic and mechanistic exploration