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Studies show that PERK inhibitors (such as integrated stress response inhibitor (ISRIB)) suppress the PERK-eIF2-ATF4 pathway, thereby reducing foam cell formation and alleviating atherosclerotic plaque burden (186)

Yildirim, A., Gumus, M., Dalga, S., Sahin, Y

CrossRef Efficacy and safety of photodynamic therapy for unresectable cholangiocarcinoma: A meta-analysis Yi Lu, Lei Liu, Jia-chuan Wu, Li-ke Bie, Biao Gong Clinics and Research in Hepatology and Gastroenterology.2015

Alcoholic fatty liver disease inhibited the co-expression of Fmo5 and PPAR to activate the NF-B signaling pathway, thereby reducing liver injury via inducing gut microbiota disturbance