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Soukup T (2014) Effects of long-term thyroid hormone level alterations, n-3 polyunsaturated fatty acid supplementation and statin administration in rats

There is often a significant loss of muscle mass and strength, and dogs may become lethargic or unresponsive

Metformin, used as treatment for type 2 diabetes, induces B12 malabsorption and has also been associated with low total serum B12 concentrations (AlFawaeir & AlOdat, 2022)