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A second established mechanism involves growth factor upregulation

However, using human fetal kidneys for experimentation poses ethical challenges

The S100 protein family interacts with specific target proteins to regulate cell proliferation, differentiation, migration, signal transduction, apoptosis, energy metastasis, and more ( Table 2 )

By obtaining the MIC of a drug against a specific bacterial strain and integrating pharmacokinetic/pharmacodynamic (PK/PD) principles, treatment regimens can be adjusted based on the dynamic changes in the patients infection status, thereby optimizing therapeutic efficacy and maximizing clinical benefits