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Church JS, Bannish JAM, Adrian LA, Rojas Martinez K, Henshaw A, Schwartzer JJ (2023) Serum short chain fatty acids mediate hippocampal BDNF and correlate with decreasing neuroinflammation following high pectin fiber diet in mice

TPMTs catalyze the S-methylation of aromatic and heterocyclic sulfur-containing compounds, such as 6-mercaptopurine (6 MP), azathioprine and 6-thioguanine, used in clinical disease treatment (Kouwenberg et al., 2020)

The aforementioned mechanisms, originating from in vitro primary cell models, indicate that ferroptosis in periodontal ligament fibroblasts serves as an active driver of soft tissue destruction