berberine + l-carnitine with l carnitine Berberine Glucose Support: Balanced Lipid Levels Berberine vs L Carnitine ,

H.HouY.LiP.XuC

All evidence comes from mouse models and cell cultures

Glossary ICH Intracerebral hemorrhage SAH Subarachnoid hemorrhage BBB Blood-brain barrier RBC Red blood cells HO-1 Heme oxygenase-1 CO Carbon monoxide TFR1 Transferrin receptor 1 STEAP3 Six-Transmembrane Epithelial Antigen of Prostate 3 LIP Labile iron pool SLC11A2 Solute Carrier Family 11 Member 2 LOXs Lipoxygenases ROS Reactive oxygen species NCOA4 Nuclear receptor coactivator 4 ATG5 Autophagy-related 5 ATG7 Autophagy-related 7 NFS1 Nitrogen fixation 1 HSPB1 Heat shock factor-binding Protein 1 PUFAs Polyunsaturated fatty acids I/R Ischemia-reperfusion GSH Glutathione MCAO Middle Cerebral Artery Occlusion RosA-LIP Osmarinic acid encapsulated in liposomes SOD Superoxide Dismutase MDA Malondialdehyde GPX4 Glutathione Peroxidase 4 ACSL4 Acyl-Co A synthetase long-chain family member 4 FTH1 Ferritin Heavy Chain 1 LDH Lactate Dehydrogenase Nrf2 Nuclear factor erythroid 2 related factor 2 Fto Fat mass and obesity-associated protein Atf3 Activation transcription factor 3 ZO-1 Zonula Occludens 1 xCT Cystine/Glutamate Antiporter COX2 Cyclooxygenase-2 4-HNE 4-Hydroxynonenal GSH-Px Glutathione peroxidase MMP-9 Matrix Metalloprotein 9 OS Oxidative stress RNS Reactive nitrogen species CNS Central Nervous System HDAC1/2 Histone deacetylases 1/2 H3K9me3 Histone H3 Lysine 9 Trimethylation Nedd4 Neural precursor cell expressed, developmentally downregulated 4 FOXO3 Forkhead box O3 CISD2 CDGSH iron sulfur domain 2 H2S H2S-producing enzymes circAFF1 circular RNA AFF1 SLC7A11 Solute Carrier Family 7 Member 11 METTL3 Methyltransferase like 3 FSP1 Ferroptosis-suppressor-protein 1 Fpn Ferroportin IRP Iron Regulatory Protein Tau microtubule-associated protein tau LncRNA PVT1 plasmacytoma variant translocation 1 SSAT1 Spermidine/spermine N1-acetyltransferase 1 UBIAD1 UbiA prenyltransferase domain containing 1 PGE2 ProstaglandinE2 FtMt Ferritin Mitochondrial USP14 ubiquitin specific peptidase 14 SIRT6 Sirtuin 6 mTOR Mechanistic Target of Rapamycin References 1 AlvarezS

PMID: 27052143