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Among the various determinants of cancer immunity, the tumor microenvironment (TME) functions as a major obstacle that severely impairs the efficacy of ICIs 2,4

This has called for new emerging strategies for improved bioavailability that include chemical modifications to stabilize the peptide, use of enzyme inhibitors, linkage to absorption enhancers, and packaging peptides using nanoparticles

If a peptide's manufacturer or supplier specifies a particular diluent, that guidance should always take priority over general defaults

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