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Peripheral mechanisms of neuropathic painthe role of neuronal and non-neuronal interactions and their implications for topical treatment of neuropathic pain

Curr Med Chem 16(11):13251348

*Correspondence: Viviana Trezza [email protected] Piemonte [email protected] These authors share first authorship These authors share last authorship This article was submitted to Molecular Psychiatry, a section of the journal Frontiers in Psychiatry Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Under oxidative stress, with the increase in ROS expression, Nrf2 is dissociated from the complex and translocated into the nucleus to bind to the promoter antioxidant response element (ARE) sequence, promoting the expression of Nrf2-related antioxidant enzymes, such as SOD, CAT, heme oxygenase-1 (HO-1), and GPx (Zhang et al., 2021