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doi: 10.3389/fphys.2017.00600

Maloney SM, Hoover CA, Morejon-Lasso LV, Prosperi JR Mechanisms of taxane resistance

attention to AMPK/Nrf2/HO-1, -Klotho/NLRP3/Caspase-1, and Caspase-3-mediated apoptosis interplay

Moreover, glial cells readily populate brain regions with active neurodegeneration, increasing the potential for high NO levels that can further exacerbate toxicity in surrounding cells