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10.1038/mp.2016.168 17 FryeR

Biochemistry 43, 33273335

Analysis of 14 paired liver biopsies revealed significantly lower baseline peripheral mtDNA copy number in NASH versus simple steatosis patients, establishing an association between mitochondrial dysfunction and disease severity

Therefore, dynamic monitoring and timely intervention targeting the gut microecology are crucial not only for acute-phase treatment but also for improving long-term neurological functional outcomes in patients