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A substantial body of research over the past decade has been transformed into the scientific and medical foundation for tobacco harm reduction, the substitution of safer sources of nicotine, including tobacco products, by those smokers who are unable or unwilling to achieve nicotine and tobacco abstinence

For example, in light of the tens of thousands of CpG sites that could be analyzed simultaneously in an EWAS, a significant proportion of reported studies might not have had a large enough sample to decrease the rate of false-positive associations evoked by multiple testing

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