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Moreover, the high dimensionality of the metabolomic profiles, relative to the available training population sample sizes, introduces a residual risk of false discovery, despite stringent feature selection and validation across independent external datasets

Here, driving expression of MMPs and decreasing the expression of TIMPs, might be a promising target to break down the fibrotic plaque

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Resistance did not appear to be driven by complete failure of SPA to activate AR, as hallmark androgen response genes remained induced in both SPA-sensitive and resistant cells (Supplemental Figure 9C)