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Specifically, excess iron within the cell, particularly the highly reactive ferrous ions, initiates lipid peroxidation through the Fenton reaction, catalyzing the peroxidation of polyunsaturated fatty acids (PUFAs) highly expressed on the cell membrane [10].The peroxidation product PUFA-OOH generated during this process has strong cytotoxicity, which can damage the cell membrane structure, increase membrane permeability, thereby accelerating the ferroptosis process and leading to myocardial injury [11]

At that point the patient may recall something like Well I did fall off the roof when I was youngerI was REAL sore for about a month, but I got better

Eur J Med Chem