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Over the past 15 years, the field of chemical protein modification has been dramatically revitalized, from one that focused on the use of natural cysteine and lysine residues to one that now utilizes a wide range of chemical handles, coupling partners and conditions, many of which are mutually compatible (orthogonal) not just with (to) each other, thereby allowing multiple modifications to be undertaken, but also with (to) living systems, allowing them to be utilized in vivo 170

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The same peptide stored at 35C