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Removing a lung and two ribs John Wayne's left lung had developed a malignant tumor, which was serious enough to require that Wayne's whole lung be removed (via The Washington Post)

Mendelian randomisation of effect of smoking on bipolar disorder When comparing the current findings to those of a previous study evaluating the relationship between smoking and other severe mental illness, Reference Wootton, Richmond, Stuijfzand, Lawn, Sallis and Taylor12 the effect sizes we found are comparable to those testing lifetime smoking and smoking initiation as a risk factor for schizophrenia and major depressive disorder

The long-term health effects of vaping are unclear though it appears to be safer than smoking in the short-term Heres the bottom line: If youre a chronic smoker looking for a nicotine fix and trying to decide between smoking and vaping, most experts would agree theres a compelling case that e-cigarettes are less harmful