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This investigator's evaluation of a drug that is still undergoing the pre-approval process makes a Phase 4 trial unlikely

doi: 10.1016/j.toxlet.2016.11.006

Nature 386 , 403407 (1997)

Statistical analysis of atherosclerotic lesions from carotid arteries revealed colocalized NF-B activation and FasL overexpression, and a similar result was also found in peripheral blood mononuclear cells (PBMCs), indicating the NF-B/FasL pathway may contribute to plaque vulnerability (102) (Figure 2C)