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And indeed there, the animal data are pretty impressive

10.1038/sj.embor.7400448 225 ZouZ.SasaguriS.RajeshK

After mating them with UBC-Cre ERT2/+ mice, TLK2 genes could be knocked out ubiquitously by tamoxifen (Sigma #T5648) via intraperitoneal injection in 75 mg/kg body weight once every 24 h for a total of 5 consecutive days

A well-functioning homocysteine pathway is important for numerous aspects of health including normal detoxification, immune function, joint and cartilage health, cardiovascular health, and brain health