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Parasites tend to thrive more in the cooler months

137 Blood Proteins as Antioxidants Human blood proteins are vulnerable to oxidative damage because free radicals can cause alterations in the electrical charge of proteins, induce cross-linking of proteins, and increase their susceptibility to proteolysis

Banks WA, Kastin AJ: Peptides and blood brain barrier: lipophilicity as predictor of permeability

The unfortunate truth is that big risk signals (lets say the kind you get from drinking antifreeze) can be spotted from the anecdotal experience of people in the world just trying things, but small-but-serious risk signals (lets say cardiovascular disease with tofacitinib) are really hard to identify without a proper trial or a proper observational study