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Mutations in genes such as SNCA, LRRK2, PARK7, PINK1, and VPS35 are associated with familial forms of PD, while pesticide exposure, heavy metals, and industrial chemicals contribute to sporadic cases

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336 While cell-based display methods typically create the genotype to phenotype linkage through compartmentalization, CFE-based selection methods, like ribosome 337 and mRNA 338 display, frequently leverage a direct physical link between a displayed protein and its transcript to maintain the genotype and phenotype linkage