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600 NASH/NAFLD HCC Non-alcoholic fatty liver disease (NAFLD) is globally prevalent and can progress to NASH, significantly increasing the risk of HCC

Most mutations (including the p.Gly376Asp) promote cytoplasmic mislocalization [20] and formation of toxic protein aggregates [21], coupled to a depletion TDP-43 in the nucleus that causes a loss of the nuclear function of the protein [22]

370 This evidence highlights the critical role of neutrophils in the pathogenesis of SLE

Measurement of LDH activity Lactate Dehydrogenase (LDH) activity was measured by a standard kit (A020-2, Nanjing Jiancheng Bioengineering, China)