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Brain Pathophysiology of PD Clinical researchers consider the pathological progress of PD in the brain initiates in the lower structures of the brainstem, followed by a caudal-to-rostral pattern as well as the involvement of the cortico-basal ganglia-cerebellar pathways

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Another study further demonstrated that the FAD/NAD(P)H-binding site of FSP1 is evolutionarily conserved among NADH quinone reductases, and targeting this region enabled the development of viFSP1, a species-independent inhibitor that interacts with the NAD(P)H-binding pocket of FSP1 121