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PAMPs from persistent pathogen components and DAMPs from mitochondrial stress synergistically activate the NLRP3 inflammasome and NF-B pathway, which are the core innate immune pathways mediating the conversion of metabolic stress into systemic inflammation

IR exposure, depending on the total absorbed dose, can lead to catastrophic toxicity ranging from organ-specific syndromes to mortality [36,37,38,39]

Shaking introduces significant mechanical stress that can break the delicate chemical bonds holding the peptide chain in its specific, functional shape

Protein S appears to play a role in the breakdown of bone mediated by osteoclasts