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Hofmeister Thomas P

miR-214 sensitizes hepatocytes to ferroptosis To investigate the biological factors responsible for regulating hepatocyte sensitivity to ferroptosis, we focused on the top 25 upregulated miRNAs in the livers of alcoholic hepatitis (AH) patients from the Gene Expression Omnibus database (accession number GSE59492)

The mechanism involves isotretinoin's activation of retinoid X receptors (RXR), which reduces hepatic lipase activity and increases very-low-density lipoprotein (VLDL) secretion

This network operates as a multidimensional system in which microbiota remodeling initiates the intervention, barrier function provides support, immune regulation drives the response, and antioxidant defenses sustain it (Xu et al., 2025)