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However, whether barrier dysfunction is causal or consequence of these systemic and metabolic diseases is controversial

Moreover, CBD attenuated the high glucose-induced enhanced ROS (reactive oxygen species) generation and cell death in human cardiomyocytes (117)

J Controll Rel 159:213 Zhang G, Liu S, Liu Y, Wang F, Ren J, Gu J, Zhou K, Shan B (2014a) A novel cyclic pentapeptide, H-10, inhibits B16 cancer cell growth and induces cell apoptosis