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First, soluble phenolic compounds are extracted from the herbal cell matrix using a supercritical fluid, followed by depressurization to separate the bioactive components, converting the supercritical fluid into a gas phase ( Supercritical fluid extraction is considered a green technology, frequently employing gases like CO 2 , CH 3 , C 2 H 6 , C 2 H 6 O, C 3 H 8 , C 6 H 6 , and NH 3 during depressurization ( Ailanthus excelsa , and Dunaliella salina ( Supercritical fluid extraction, particularly with supercritical carbon dioxide (CO 2 ), offers several advantages for the extraction of polyphenols ( 2 , resulting in solvent-free extracts that are safe for food, pharmaceutical, and cosmetic uses

Although the majority of butyrate is consumed locally by colonocytes as a primary energy source, a remaining fraction enters the systemic circulation, crosses the bloodbrain barrier, and retains potent neuroprotective actions, making it both a key colonic fuel and a systemically active neuromodulatory metabolite