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[PubMed] [Google Scholar][69] Glacet-Bernard A, Coscas G, Chabanel A, et al

These adipocyte-derived FAs promote the expression of G0S2, the hormone fibroblast growth factor 21 (FGF21) (149) and genes involved in FAO (150), and regulate liver FAO and very low-density lipoprotein (VLDL) secretion (150)

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Create functional folate deficiency (a buildup of inactive folate that can't do its job), because B12 is a cofactor for the enzyme that turns inactive folate into active folate