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Moreover, the interaction between DNA methylation and various epigenetic mechanisms, such as non-coding RNAs and histone modifications, can be harnessed to create combinatorial epigenetic therapies that simultaneously target multiple regulatory layers, potentially improving treatment efficacy ( Even though these are good signs, there are still some big problems that need to be fixed before epigenetic therapies can be used regularly in AS

Moreover, ROS accumulation, p53 activation, and Nrf2 signaling pathway activation all induced autophagy and ferroptosis

Reconstituted solutions are typically kept at 28 C and used within weeks, with long-term storage as frozen aliquots to minimize freeze-thaw degradation

Wang HY, Peng HC, Chien YW, Chen YL, Lu NS, Yang SC