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Statements Author contributions QH: Supervision, Conceptualization, Writing original draft, Funding acquisition

Furthermore, in patients with HCV-related chronic liver disease, levels of taurine-conjugated BAs strongly correlated with increased hepatic S1PR2 expression, markers of inflammation (NLRP3 inflammasome, NF-B pathway genes), and liver disease severity, suggesting a pathological role for the Tau-BA-S1PR2 axis in hepatic inflammation (104)

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These findings underscore that GSH regulates ferroptosis not only through peroxide detoxification but also by coordinating iron trafficking and Fe-S cluster integrity, thereby coupling redox defense to core metabolic fitness