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Reactive oxygen species (ROS), traditionally viewed as damaging metabolic byproducts, are now recognized as critical signaling molecules in the brain, where they modulate various neural functions including synaptic plasticity, neurogenesis, and circadian rhythm regulation

Elevated heart rate, a heightened sense of awareness and a surge of adrenaline come in handy when you need to wrestle an alligator or run from a grizzly

Even a modest reduction in Vitamin B 12 status will cause elevation of plasma homocysteine (Scott, 12 deficiency

CR can activate numerous endocrine and neurobiological responses ranging from the systemic level to molecular signaling pathways