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5E, G) and BxPC-3 cells (Fig

Intercellular connections including tight junction proteins such as zonula occludens (ZO)-1, occludin, claudin-1, and E-cadherin, desmosomes, and intercellular adhesion molecules enable the epithelial barrier to fulfil its protecting role against environmental toxicants ( Indeed, studies have demonstrated that exposure to PM can lead to increased epithelial permeability of human nasal epithelial cells, as indicated by increased paracellular permeability and decreased transepithelial electrical resistance ( 2.5 mediated reactive oxygen species (ROS) generation in nasal epithelial cells, preventing barrier dysfunction