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The fatigue tied to B12 deficiency is often a deep, ongoing exhaustion that rest does not fully relieve

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Deficiency of 1 -antitrypsin presents in infancy as liver disease, or in adulthood as lung disease 1 -Antitrypsin is a member of the serpin family of serine protease inhibitors, and, contrary to its name, its predominant target is macrophage-derived elastase

If it is just B12, be sure that the doctor monitors your blood levels so that you do not get too much